Please join us in welcoming Dr. George Tan Associate Professor, Texas Tech University, Dept. of Industrial, Manufacturing and Systems Engineering.
https://ncsu.zoom.us/j/94149698177?pwd=bmphR2wzeTZEcm0xSU9SandQNWJodz09
Meeting ID: 941 4969 8177
Passcode: 663953
A Hybrid Biofabrication Strategy for Soft Tissue Scaffolds Embedded with Artificial Capillary Vessels
The advancement of biofabrication has been significant, yet the challenge of vascularizing sizable tissue scaffolds persists as a critical hurdle in tissue engineering. The absence of capillary vessels often leads to cellular necrosis due to insufficient oxygen and nutrient supply. The development of scaffolds that integrate capillary structures is crucial for sustaining cellular metabolism and the successful creation of large tissues and organs. This study introduces an innovative hybrid biofabrication technique that synergizes coaxial wet electrospinning with extrusion-based bioprinting to produce hydrogel scaffolds embedded with porous microtubes. These porous microtubes are designed to emulate natural capillary structures and are integrated within layers of a 3D-printed sodium alginate scaffold, establishing a microchannel system that facilitates mass diffusion and enhances cell viability.
George Tan is an Associate Professor and the Ed and Linda Whitacre Faculty Fellow in the Department of Industrial, Manufacturing, and Systems Engineering at TRohan Shirwaiker in 2015. His research focuses on Bioinspired Hybrid Manufacturing, intertwining the disciplines of additive manufacturing, microfabrication technologies, and biomaterials. At the core of his research are two synergistic sub-fields: BioFab, which focuses on biofabrication technologies for tissue repair, and MedFab, which emphasizes the rapid prototyping of medical devices and implants. Tan has been recognized by the National Science Foundation CAREER award, the Junior investigator Research Award by the Biomedical Engineering Society Advanced Biomanufacturing Group, and the Innovation Award by the TechConnect World Innovation Conference among others. To date, Tan has published 38 refereed journal papers and 18 conference papers.
