Rohan Shirwaiker

Professor, Pleasant ISE Faculty Scholar, and University Faculty Scholar

Rohan Shirwaiker is a professor in ISE and Associate Director of the Functional Tissue Engineering Program at the Comparative Medicine Institute (CMI). He is also an associate faculty of the Department of Mechanical and Aerospace Engineering and the Joint Department of Biomedical Engineering.

Shirwaiker’s 3D Tissue Manufacturing research group focuses on the design and scalable manufacturing of tissue-engineered medical products (TEMPs). They engineer new 3D biofabrication processes (e.g., ultrasound-assisted bioprinting, 3D melt and solution blowing), biomimetic TEMP designs (e.g., for musculoskeletal applications), and non-destructive quality monitoring techniques (e.g., dielectric spectroscopy, ultrasound spectroscopy). Using computational, experimental, and clinical approaches synergistically, they investigate fundamental interrelationships between critical process parameters, biomaterials, and functional quality attributes of TEMPs for various therapeutic and diagnostic applications. Shirwaiker’s research is highly multidisciplinary and collaborative and has been supported by grants from the National Science Foundation (CMMI, CBET), National Institutes of Health (NIAMS, NIDCR), US Department of Defense (ARMI BiofabUSA), Orthopaedic Research and Education Foundation (OREF), Eshelman Institute for Innovation, and other funding agencies and industry. He has co-authored over 125 journal articles, conference proceedings and book chapters, and has 3 issued/pending patents. He has been recognized by several awards including the NSF CAREER Award, SME Outstanding Young Manufacturing Engineer Award, SME Distinguished Faculty Advisor Award, IISE Manufacturing & Design Outstanding Young Investigator Award, and C. A. Anderson Outstanding Faculty Award.

Shirwaiker teaches undergraduate and graduate courses related to design and manufacturing, including ISE 316 (Manufacturing Engineering I: Processes), ISE 498 (Senior Design Project), ISE 589 (Intro to Biomedical Design and Manufacturing), and ISE 714 (Product Manufacturing for Medical Device Industry). He currently serves as the elected Senior Vice-President of Technical Operations on the IISE Board of Trustees. He also serves on SME NAMRI Scientific Committee and ASME Bioprinters Hardware Standards Committee.
 

Research Interests

3D Biofabrication and Bioprinting, Tissue Engineering and Regenerative Medicine, Additive Manufacturing, Medical Product Development
 

Education

DegreeProgramSchoolYear
Ph.D.Doctorate on Philosophy in Industrial EngineeringPennsylvania State University2011
MSMaster of SciencePennsylvania State University2007
BSBachelor of ScienceUniversity of Mumbai2005
 

Honors and Awards

 

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Publications

Investigating dielectric spectroscopy and soft sensing for nondestructive quality assessment of engineered tissues
Shohan, S., Zeng, Y., Chen, X., Jin, R., & Shirwaiker, R. (2022), BIOSENSORS & BIOELECTRONICS, 11. https://doi.org/10.1016/j.bios.2022.114286
Multiphase CFD Modeling and Experimental Validation of Polymer and Attenuating Air Jet Interactions in Nonwoven Annular Melt Blowing
Schuchard, K. G., Pawar, A., Anderson, B., Pourdeyhimi, B., & Shirwaiker, R. A. (2022), INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 9. https://doi.org/10.1021/acs.iecr.2c01710
Multiscale Anisotropic Tissue Biofabrication via Bulk Acoustic Patterning of Cells and Functional Additives in Hybrid Bioinks
Chansoria, P., Asif, S., Gupta, N., Piedrahita, J., & Shirwaiker, R. A. (2022, January 27), ADVANCED HEALTHCARE MATERIALS, Vol. 1. https://doi.org/10.1002/adhm.202102351
Biofabricated 3D in vitro model of fibrosis-induced abnormal hepatoblast/biliary progenitors' expansion of the developing liver
Brovold, M., Keller, D., Devarasetty, M., Dominijanni, A., Shirwaiker, R., & Soker, S. (2021, June 5), BIOENGINEERING & TRANSLATIONAL MEDICINE, Vol. 12. https://doi.org/10.1002/btm2.10207
Cell-Laden Nanocellulose/Chitosan-Based Bioinks for 3D Bioprinting and Enhanced Osteogenic Cell Differentiation
Maturavongsadit, P., Narayanan, L. K., Chansoria, P., Shirwaiker, R., & Benhabbour, S. R. (2021), ACS APPLIED BIO MATERIALS, 4(3), 2342–2353. https://doi.org/10.1021/acsabm.0c01108
Characterizing the Effects of Synergistic Thermal and Photo-Cross-Linking during Biofabrication on the Structural and Functional Properties of Gelatin Methacryloyl (GeIMA) Hydrogels
Chansoria, P., Asif, S., Polkoff, K., Chung, J., Piedrahita, J. A., & Shirwaiker, R. A. (2021), ACS BIOMATERIALS SCIENCE & ENGINEERING, 11. https://doi.org/10.1021/acsbiomaterials.1c00635
Fabrication of drug-loaded ultrafine polymer fibers via solution blowing and their drug release kinetics
Schuchard, K., Joijode, A., Willard, V. P., Anderson, B., Grondin, P., Pourdeyhimi, B., & Shirwaiker, R. (2021), 49TH SME NORTH AMERICAN MANUFACTURING RESEARCH CONFERENCE (NAMRC 49, 2021). https://doi.org/10.1016/j.promfg.2021.06.017
Non-destructive quality monitoring of 3D printed tissue scaffolds via dielectric impedance spectroscopy and supervised machine learning
Shohan, S., Harm, J., Hasan, M., Starly, B., & Shirwaiker, R. (2021), 49TH SME NORTH AMERICAN MANUFACTURING RESEARCH CONFERENCE (NAMRC 49, 2021). https://doi.org/10.1016/j.promfg.2021.06.063
Steroid eluting biocompatible stent for subglottic stenosis
Manzi, B., Shirwaiker, R., Gungor, A., & Weinberger, P. (2021), EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. https://doi.org/10.1007/s00405-020-06562-y
The evaluation of a multiphasic 3D-bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model
Nordberg, R. C., Huebner, P., Schuchard, K. G., Mellor, L. F., Shirwaiker, R. A., Loboa, E. G., & Spang, J. T. (2021, June 10), JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol. 6. https://doi.org/10.1002/jbm.b.34886

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Rohan Shirwaiker