Rohan Shirwaiker

Associate Professor

Rohan Shirwaiker is an Associate Professor in ISE and Associate Director of the Functional Tissue Engineering Program at the Comparative Medicine Institute (CMI). He is also an associate faculty of the Department of Mechanical and Aerospace Engineering and the Joint Department of Biomedical Engineering.

Shirwaiker’s 3D Tissue Manufacturing research group focuses on the design and scalable manufacturing of tissue-engineered medical products (TEMPs). They engineer new 3D biofabrication processes (e.g., ultrasound-assisted bioprinting, 3D melt and solution blowing), biomimetic TEMP designs (e.g., for musculoskeletal applications), and non-destructive quality monitoring techniques (e.g., dielectric spectroscopy, ultrasound spectroscopy). Using computational, experimental, and clinical approaches synergistically, they investigate fundamental interrelationships between critical process parameters, biomaterials, and functional quality attributes of TEMPs for various therapeutic and diagnostic applications. Shirwaiker’s research is highly multidisciplinary and collaborative and has been supported by grants from the National Science Foundation (CMMI, CBET), National Institutes of Health (NIAMS, NIDCR), US Department of Defense (ARMI BiofabUSA), Orthopaedic Research and Education Foundation (OREF), Eshelman Institute for Innovation, and other funding agencies and industry. He has co-authored over 125 journal articles, conference proceedings and book chapters, and has 3 issued/pending patents. He has been recognized by several awards including the NSF CAREER Award, SME Outstanding Young Manufacturing Engineer Award, SME Distinguished Faculty Advisor Award, IISE Manufacturing & Design Outstanding Young Investigator Award, and C. A. Anderson Outstanding Faculty Award.

Shirwaiker teaches undergraduate and graduate courses related to design and manufacturing, including ISE 316 (Manufacturing Engineering I: Processes), ISE 498 (Senior Design Project), ISE 589 (Intro to Biomedical Design and Manufacturing), and ISE 714 (Product Manufacturing for Medical Device Industry). He currently serves as the elected Senior Vice-President of Technical Operations on the IISE Board of Trustees. He also serves on SME NAMRI Scientific Committee and ASME Bioprinters Hardware Standards Committee.
 

Research Interests

3D Biofabrication and Bioprinting, Tissue Engineering and Regenerative Medicine, Additive Manufacturing, Medical Product Development
 

Education

DegreeProgramSchoolYear
Ph.D.Doctorate on Philosophy in Industrial EngineeringPennsylvania State University2011
MSMaster of SciencePennsylvania State University2007
BSBachelor of ScienceUniversity of Mumbai2005
 

Honors and Awards

 

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Publications

Biofabricated 3D in vitro model of fibrosis-induced abnormal hepatoblast/biliary progenitors' expansion of the developing liver
Brovold, M., Keller, D., Devarasetty, M., Dominijanni, A., Shirwaiker, R., & Soker, S. (2021, June 5), BIOENGINEERING & TRANSLATIONAL MEDICINE, Vol. 12. https://doi.org/10.1002/btm2.10207
Cell-Laden Nanocellulose/Chitosan-Based Bioinks for 3D Bioprinting and Enhanced Osteogenic Cell Differentiation
Maturavongsadit, P., Narayanan, L. K., Chansoria, P., Shirwaiker, R., & Benhabbour, S. R. (2021), ACS APPLIED BIO MATERIALS, 4(3), 2342–2353. https://doi.org/10.1021/acsabm.0c01108
Steroid eluting biocompatible stent for subglottic stenosis
Manzi, B., Shirwaiker, R., Gungor, A., & Weinberger, P. (2021), EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. https://doi.org/10.1007/s00405-020-06562-y
The evaluation of a multiphasic 3D-bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model
Nordberg, R. C., Huebner, P., Schuchard, K. G., Mellor, L. F., Shirwaiker, R. A., Loboa, E. G., & Spang, J. T. (2021, June 10), JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol. 6. https://doi.org/10.1002/jbm.b.34886
3D bioprinting of anisotropic engineered tissue constructs with ultrasonically induced cell patterning
Chansoria, P., & Shirwaiker, R. (2020), ADDITIVE MANUFACTURING, 32. https://doi.org/10.1016/j.addma.2020.101042
Effects of Autoclaving, EtOH, and UV Sterilization on the Chemical, Mechanical, Printability, and Biocompatibility Characteristics of Alginate
Chansoria, P., Narayanan, L. K., Wood, M., Alvarado, C., Lin, A., & Shirwaiker, R. A. (2020), ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(9), 5191–5201. https://doi.org/10.1021/acsbiomaterials.0c00806
Experimental Characterization and Finite Element Modeling of the Effects of 3D Bioplotting Process Parameters on Structural and Tensile Properties of Polycaprolactone (PCL) Scaffolds
Narayanan, L. K., & Shirwaiker, R. (2020), Applied Sciences, 10(15), 5289. https://doi.org/10.3390/app10155289
High-Throughput Manufacture of 3D Fiber Scaffolds for Regenerative Medicine
Shirwaiker, R. A., Fisher, M. B., Anderson, B., Schuchard, K. G., Warren, P. B., Maze, B., … Pourdeyhimi, B. (2020), TISSUE ENGINEERING PART C-METHODS, 26(7), 364–374. https://doi.org/10.1089/ten.tec.2020.0098
Process hybridization schemes for multiscale engineered tissue biofabrication
Chansoria, P., Schuchard, K., & Shirwaiker, R. A. (2020), WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, Vol. 13. https://doi.org/10.1002/wnan.1673
Review: Modeling in Situ Liver Cancer
, (2020). Annals of Gastroenterology and Digestive Disorders.

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Rohan Shirwaiker