Rohan Shirwaiker

Associate Professor

Rohan Shirwaiker is an Associate Professor in ISE and an Associate faculty member of the UNC-NCSU Joint Department of Biomedical Engineering. He is also the Associate Director of the Functional Tissue Engineering Program at the Comparative Medicine Institute (CMI).

Dr. Shirwaiker’s 3D Tissue Manufacturing research group focuses on advancing the science and technology for scalable manufacturing of engineered tissues. They study the fundamental relationships between 3D biofabrication processes, biomaterials, and critical-to-quality attributes of engineered tissues, and develop new tissue manufacturing strategies and platforms. Dr. Shirwaiker’s research is highly multidisciplinary and collaborative and has been supported by over $2.5 million in research grants from the National Science Foundation (NSF), Orthopaedic Research and Education Foundation (OREF), and Advanced Regenerative Manufacturing Institute (ARMI), and other funding agencies. He has co-authored over 100 journal articles, conference proceedings and book chapters, and has 3 patents on biomedical devices and processing technologies. He has been recognized by several awards including the NSF CAREER Award, SME Outstanding Young Manufacturing Engineer Award, SME Distinguished Faculty Advisor Award, IISE Manufacturing & Design Outstanding Young Investigator Award, and C. A. Anderson Outstanding Faculty Award.

Dr. Shirwaiker teaches undergraduate and graduate courses related to design and manufacturing, including ISE 316 (Manufacturing Engineering I: Processes), ISE 498 (Senior Design Project), ISE 589 (Intro to Biomedical Design and Manufacturing), and ISE 714 (Product Manufacturing for Medical Device Industry). He is the faculty advisor of the SME student chapter at NC State. He serves on the advisory committees of IISE’s Manufacturing & Design division and SME’s North American Manufacturing Research Institution and is a Program Chair of the 2020 IISE Annual Conference.

Education

Ph.D. 2011

Doctorate on Philosophy in Industrial Engineering

Pennsylvania State University

MS 2007

Master of Science

Pennsylvania State University

BS 2005

Bachelor of Science

University of Mumbai

Research Description

3D Biofabrication, Bioprinting, Tissue Engineering and Regenerative Medicine, Orthopaedics, Medical Product Development

Honors and Awards

Publications

Characterizing the Process Physics of Ultrasound-Assisted Bioprinting
Chansoria, P., & Shirwaiker, R. (2019), SCIENTIFIC REPORTS, 9. https://doi.org/10.1038/s41598-019-50449-w
Investigation of multiphasic 3D-bioplotted scaffolds for site-specific chondrogenic and osteogenic differentiation of human adipose-derived stem cells for osteochondral tissue engineering applications
Mellor, L. F., Nordberg, R. C., Huebner, P., Mohiti-Asli, M., Taylor, M. A., Efird, W., … Loboa, E. G. (2019), JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. https://doi.org/10.1002/jbm.b.34542
Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment
Huebner, P., Warren, P. B., Chester, D., Spang, J. T., Brown, A. C., Fisher, M. B., & Shirwaiker, R. A. (2019), CONNECTIVE TISSUE RESEARCH. https://doi.org/10.1080/03008207.2019.1624733
The Ion Delivery Manner Influences the Antimicrobial Efficacy of Silver Oligodynamic Iontophoresis
Tan, G. Z., Orndorff, P. E., & Shirwaiker, R. A. (2019), JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 39(4), 622–631. https://doi.org/10.1007/s40846-018-0447-1
Ultrasound-assisted biofabrication and bioprinting of preferentially aligned three-dimensional cellular constructs
Chansoria, P., Narayanan, L. K., Schuchard, K., & Shirwaiker, R. (2019), BIOFABRICATION, 11(3). https://doi.org/10.1088/1758-5090/ab15cf
Label free process monitoring of 3D bioprinted engineered constructs via dielectric impedance spectroscopy
Narayanan, L. K., Thompson, T. L., Shirwaiker, R., & Starly, B. (2018), Biofabrication, 10(3). https://doi.org/10.1088/1758-5090/aaccbf
Antibacterial efficacy and cytotoxicity of low intensity direct current activated silver–titanium implant system prototype
Tan, Z., Havell, E. A., Orndorff, P. E., & Shirwaiker, R. (2017), BioMetals, 30(1), 113–125. https://doi.org/10.1007/s10534-017-9993-1
Effects of 3D-bioplotted polycaprolactone scaffold geometry on human adipose-derived stem cell viability and proliferation
Mehendale, S. V., Mellor, L. F., Taylor, M. A., Loboa, E. G., & Shirwaiker, R. (2017), Rapid Prototyping Journal, 23(3), 534–542. https://doi.org/10.1108/rpj-03-2016-0035
Engineering 3D-Bioplotted scaffolds to induce aligned extracellular matrix deposition for musculoskeletal soft tissue replacement
Warren, P. B., Huebner, P., Spang, J. T., Shirwaiker, R., & Fisher, M. B. (2017), Connective Tissue Research, 58(3-4), 342–354. https://doi.org/10.1080/03008207.2016.1276177
Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications
Mellor, L. F., Huebner, P., Cai, S., Mohiti-Asli, M., Taylor, M. A., Spang, J., … Loboa, E. G. (2017), BioMed Research International, 2017. https://doi.org/10.1155/2017/6956794

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