Rohan Shirwaiker

Associate Professor

Rohan Shirwaiker is an Associate Professor in ISE and an Associate faculty member of the UNC-NCSU Joint Department of Biomedical Engineering (BME), Center for Additive Manufacturing and Logistics (CAMAL), and Comparative Medicine Institute (CMI).

Dr. Shirwaiker directs activities of the multidisciplinary 3D Tissue Biofabrication research group which focuses on design and scalable manufacturing technologies for engineered tissues. The group studies the fundamental interrelationships between biofabrication processes and biomaterials, and their effects on the critical-to-quality attributes of 3D scaffolds and cellular constructs. This knowledge is then utilized to develop new manufacturing strategies and tissue engineered medical products, primarily in orthopaedics, in collaboration with surgeons and biomedical engineers.

Dr. Shirwaiker’s research has been supported by over $1.5 million in research grants from the National Science Foundation (NSF), Orthopaedic Research and Education Foundation (OREF), Kenan Institute for Engineering, Technology and Science, and other extramural and internal funding agencies. He has co-authored 25 journal articles, 60 conference proceedings, 2 book chapters and 1 US patent in the field. He has been recognized by several distinguished awards including, most recently, the 2017 NSF CAREER Award and the 2017 C. A. Anderson Outstanding Faculty Award.

Dr. Shirwaiker teaches undergraduate and graduate ISE courses related to design and manufacturing, including ISE 316 (Manufacturing Engineering I: Processes), ISE 498 (Senior Design Project), ISE 589 (Intro to Biomedical Design and Manufacturing), and ISE 714 (Product Manufacturing for Medical Device Industry). He is the faculty advisor to the NC State student chapter of SME and the President-elect of the Manufacturing & Design Division of the Institute of Industrial and Systems Engineers. He also serves on the SME Member Council.

Education

Ph.D. 2011

Doctorate on Philosophy in Industrial Engineering

Pennsylvania State University

MS 2007

Master of Science

Pennsylvania State University

BS 2005

Bachelor of Science

University of Mumbai

Research Description

3D Biofabrication, Bioprinting, Tissue Engineering and Regenerative Medicine, Orthopaedics, Medical Product Development

Honors and Awards

Publications

Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment
Huebner, P., Warren, P. B., Chester, D., Spang, J. T., Brown, A. C., Fisher, M. B., & Shirwaiker, R. A. (2019), CONNECTIVE TISSUE RESEARCH. https://doi.org/10.1080/03008207.2019.1624733
The Ion Delivery Manner Influences the Antimicrobial Efficacy of Silver Oligodynamic Iontophoresis
Tan, G. Z., Orndorff, P. E., & Shirwaiker, R. A. (2019), JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 39(4), 622–631. https://doi.org/10.1007/s40846-018-0447-1
Ultrasound-assisted biofabrication and bioprinting of preferentially aligned three-dimensional cellular constructs
Chansoria, P., Narayanan, L. K., Schuchard, K., & Shirwaiker, R. (2019), BIOFABRICATION, 11(3). https://doi.org/10.1088/1758-5090/ab15cf
Label free process monitoring of 3D bioprinted engineered constructs via dielectric impedance spectroscopy
Narayanan, L. K., Thompson, T. L., Shirwaiker, R., & Starly, B. (2018), Biofabrication, 10(3). https://doi.org/10.1088/1758-5090/aaccbf
Antibacterial efficacy and cytotoxicity of low intensity direct current activated silver–titanium implant system prototype
Tan, Z., Havell, E. A., Orndorff, P. E., & Shirwaiker, R. (2017), BioMetals, 30(1), 113–125. https://doi.org/10.1007/s10534-017-9993-1
Effects of 3D-bioplotted polycaprolactone scaffold geometry on human adipose-derived stem cell viability and proliferation
Mehendale, S. V., Mellor, L. F., Taylor, M. A., Loboa, E. G., & Shirwaiker, R. (2017), Rapid Prototyping Journal, 23(3), 534–542. https://doi.org/10.1108/RPJ-03-2016-0035
Engineering 3D-Bioplotted scaffolds to induce aligned extracellular matrix deposition for musculoskeletal soft tissue replacement
Warren, P. B., Huebner, P., Spang, J. T., Shirwaiker, R., & Fisher, M. B. (2017), Connective Tissue Research, 58(3-4), 342–354. https://doi.org/10.1080/03008207.2016.1276177
Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications
Mellor, L. F., Huebner, P., Cai, S., Mohiti-Asli, M., Taylor, M. A., Spang, J., … Loboa, E. G. (2017), BioMed Research International, 2017. https://doi.org/10.1155/2017/6956794
Investigating dielectric impedance spectroscopy as a non-destructive quality assessment tool for 3D cellular constructs
Narayanan, L. K., Thompson, T. L., Bhat, A., Starly, B., & Shirwaiker, R. (2017), In Proceedings of the ASME 12th International Manufacturing Science and Engineering Conference - 2017, vol 4. https://doi.org/10.1115/msec2017-2725
Investigating dielectric impedance spectroscopy as a non-destructive quality assessment tool for 3D cellular constructs
Narayanan, L. K., Thompson, T. L., Bhat, A., Starly, B., & Shirwaiker, R. A. (2017), In ASME 2017 12th International Manufacturing Science and Engineering Conference, MSEC 2017 collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing (Vol. 4). https://doi.org/10.1115/MSEC20172725

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