Advisor: Dr. Binil Starly
Master of Industrial Engineering
NC State University
Bachelor of Technology
NIT Kurukshetra, India
Arun’s research area focuses on techniques for utilizing the third dimension to expand mammalian cells, particularly stem cells. He researches new methodologies in encapsulating these cell types within hydrogel based microbeads followed by long term culture in an industrial scale perfusion bioreactor. His current area of research is modelling the growth and viability of mesenchymal stem cells in rotating wheel bioreactor where he applies process modeling and statistics to develop a computation model of the bioreactor system.
This work investigates the effect of key process parameters, metabolite concentrations and bioreactor operating parameters on stem cells growth, viability and proliferation over 21 - 30 days of culture. This research would play an important role in achieving production level quantities of billions to even trillions of anchorage dependent stem cells for regenerative medicine therapy and tissue engineering applications. Furthermore, it would address some of the challenges in the field of cellular biomanufacturing to achieve the desired cellular yield while adhering to the key pillars of Good Manufacturing Practices (GMP) - safety, purity, stability, potency and identity.
- Human mesenchymal stem cells expansion on three-dimensional (3D) printed poly-styrene (PS) scaffolds in a perfusion bioreactor
- Kumar, A., Lau, W., & Starly, B. (2017), In 3rd cirp conference on biomanufacturing. (Procedia CIRP, 65) (pp. 115-120).
- Modeling human mesenchymal stem cell expansion in vertical wheel bioreactors using lactate production rate in regenerative medicine biomanufacturing
- Kumar, A., & Starly, B. (2016), (Proceedings of the ASME 11th International Manufacturing Science and Engineering Conference, 2016, vol 2, ).
- Large scale industrialized cell expansion: Producing the critical raw material for biofabrication processes
- Kumar, A., & Starly, B. (2015), Biofabrication, 7(4).