SEMINAR SERIES: The Three B’s of Regenerative Medicine Manufacturing | Dr. Binil Starly

The Three B’s of Manufacturing in Regenerative Medicine “Bioreactors, Biofabrication and Blockchain”

The ISE Department welcomes our own Dr. Binil Starly. Dr. Starly is an Associate Professor and Co-Director of the Functional Tissue Engineering Group at the Comparative Medicine Institute. He will discuss the three B’s of manufacturing in regenerative medicine: bioreactors, biofabrication, and blockchain.

As always refreshments are available in 428 Daniels Hall 30 minutes before the seminar begins.

Abstract

Regenerative Medicine is potentially transformative for patients who have diseased tissue or organs caused by trauma, genetic abnormalities or untreatable diseased states. Engineered tissue and organoid systems promises to stimulate the patient’s own healing mechanism for functional restoration. However, these lab-based innovations require treatments to reach large number of patients in a clinical setting, often with personalized intervention. This presentation will identify three promising biomanufacturing platforms, necessary for the ‘scale-out’ production of
engineered tissue/organoids. Core technology within each of these platforms will be necessary for the automation and standardization of processes and systems for the commercialization of these ‘living’ products. The first platform technology – Biofabrication, the digitally driven fabrication of 3D scaffolds and printed constructs for tissue and organ based regenerative approaches. The second platform is – Bioreactors, a necessary component in the culture of patient derived therapeutic cells to clinically relevant quantities, often in the millions to billions of cells. The third platform that we believe will be game changing to the handling of medical data across machines and enterprise systems – Blockchain, a decentralized platform for the protection and integrity of product information across the supply chain. In each of these platforms, I will show examples of our past and current work in building the core technology assets for the biomanufacturing of regenerative medicine products.

Bio

Dr. Binil Starly is an Associate Professor in the Industrial and Systems Engineering at North Carolina State University (NCSU) and Co-Director of the Functional Tissue Engineering Group, Comparative Medicine Institute. He has received the National Science Foundation CAREER award for research in engineering living tissue systems, the SME Young Manufacturing Engineer and other teaching awards. He has over 80 peer reviewed journal publications/conference proceedings and awarded 1 US Patent in the field of micro-organ devices. He currently teaches Product Development, Digital/Smart Manufacturing and Additive Manufacturing courses. His current research activities can be found at http://www.dimelab.org.