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SEMINAR SERIES: Lena Abu-El-Haija | Parth Chansoria

February 8, 2019 @ 11:00 am - 12:00 pm

FREE
SEMINAR SERIES: Abu-El-Haija | Parth Chansoria

Please join not one, but two ISE Ph.D. students, Lena Abu-El-Haija and Parth Chansoria. Lena will be discussing her pancreatic cancer prioritization and screening evaluation tool research. Parth will be discussing he is developing a new ultrasound-assisted 3D bioprinting process for fabricating anisotropic tissues.

As always refreshments are available in 428 Daniels Hall 30 minutes before the seminar begins.

Abu-El-Haija’s Abstract

Pancreatic Cancer Prioritization and Screening Evaluation Tool

Pancreatic cancer (PC) is the fourth cause of death due to cancer and is projected to be second by 2030. The incidence of PC is relatively low but the mortality risk is high with only a 6-8% five-year survival rate. PC can be asymptomatic which often leads to late diagnosis of the disease after the tumor may have metastasized to other organs. The only true cure for PC is surgical removal of the tumor at an early stage, thus, it is vital to increase early diagnosis of PC. We propose a simulation model that mimics the natural history of pancreatic cancer. We overlay the progression model with different screening policies where the screening starts at age 50 and continues until age 100, and seven screening intervals were tested; half a year, a year, two years, three years, four years, five years, and ten years. This talk presents the pancreatic cancer progression model and compares the results of the screening policies.

Abu-El-Haija’s Bio

Lena is a fifth year PhD student and part of the health systems group in ISE under the advisement of Dr. Julie Ivy

Chansoria’s Abstract

Engineering New Ultrasound-assisted 3D Bioprinting Process for Fabricating Anisotropic Tissues

Currently, there are about 110,000 people needing a life-saving organ transplant in the USA, with only 17,000 donors available and rejection rates as high as 50% (data from US OPTN). To address this problem, new technologies are aiming to create tissues and organs in labs. A critical consideration in engineering such tissues is to recapitulate the micro-structural organization of native tissues that is essential to their function. To achieve this, we are developing a new 3D bioprinting process that utilizes sound waves to organize cells into patterns which mimic the architecture of the native human tissue. Using multiphysics modeling and experimental design, we establish the key process-structure-function interactions that govern the characteristics of the tissues fabricated using the proposed method. We also demonstrate the 3D bioprinting of a knee meniscus construct featuring physiologically-relevant circumferential organization of stem cells. With the incorporation of cellular alignment within bioprinted constructs, this method allows for achieving greater complexity in the fabricated tissues as compared to conventional scaffold-based fabrication techniques, thereby contributing to the advancement of scalable biomimetic tissue manufacturing science and technology.

Chansoria’s Bio

Parth is a doctoral student and a Provost’s fellow in the ISE department under the advisement of Dr. Rohan Shirwaiker. His current research focuses on engineering a new scalable ultrasound-assisted 3D-bioprinting process that utilizes patient’s own cells to create engineered tissues with patient-specific geometry and biomechanical properties. For this research, he has received the 2nd place in student best-paper award in M&D category in 2018 IISE annual conference, and 3rd place in 2018 NC State graduate symposium. He also received the COE master scholar of the year award for the academic year 2017-18. He is a current officer in the SME student chapter and is involved in its activities on increasing the outreach of advanced manufacturing to current and future NC state students.

Details

Date:
February 8, 2019
Time:
11:00 am - 12:00 pm
Cost:
FREE
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Venue

434 | 111 Lampe Drive
111 lampe Drive
Raleigh, 27607 United States
Phone:
919-515-2362
View Venue Website

Organizer

ISE Department
Phone:
919-515-2362
Email:
ise@ncsu.edu
View Organizer Website